Kent will play Leeward Island Hurricanes, Guyana Jaguars, Jamaica Scorpions and USA on the 2018 FGS Plant Tour.
The Spitfires have been drawn in the West Indies Super50 Group B based in Antigua with the opening game on Wednesday 31 January against seven-times champions Guyana.
Each side will play their four group opponents twice with the last group match on Sunday 18 February against hosts and four-time winners Leeward Islands.
It will be the first time Kent have played the US national side and the first time against an American side since a tour match against the Gentlemen of Philadelphia at Canterbury in 1908.
The county played in the United States on a landmark tour in September-October 1903 when they played in Philadelphia, New York and Pennsylvania.
Kent could face familiar opposition with Hampshire in Group A and the top two from each group competing in the semi-finals taking place on 21-22 February before the final on Saturday 24 February.
Supporter tour packages are now available from our overseas travel partners Smile Group Travel.
Official tour packages include all-inclusive accommodation, flights, airport and matchday transfers, a souvenir tour polo shirt and a chance to meet the squad.
Prices start at £1,595 per person based on two people sharing. For more details, e-mail our official overseas travel partner Smile Group Travel or call 01708 893 250 (weekdays 9am to 5.30pm).
Group A (in Barbados): Barbados Pride, Combined Campuses Marooners, Hampshire, Trinidad & Tobago Red Force, Windward Volcanoes.
Group B (in Antigua): Leeward Islands Hurricanes, Guyana Jaguars, Jamaica Scorpions, Kent, USA.
2018 FGS Plant Tour fixtures (1pm GMT at Sir Vivian Richards Stadium unless stated):
31 Jan: Guyana Jaguars v Kent*, 4 Feb: Jamaica Scorpions v Kent, 6 Feb: Leeward Islands Hurricanes v Kent, 8 Feb: USA v Kent, 10 Feb: Guyana Jaguars v Kent (6pm GMT at Coolidge Cricket Ground), 14 Feb: Jamaica Scorpions v Kent, 16 Feb: USA v Kent, 18 Feb: Leeward Islands Hurricanes v Kent (6pm GMT at Coolidge Cricket Ground).
Semi-Finals (6pm GMT at Coolidge Cricket Ground) – 21 Feb: Group A winner v Group B runner-up, 22 Feb: Group B winner v Group A runner-up
Final to be played on 24 Feb (6pm GMT at Coolidge Cricket Ground, reserve day 25 February)